837 Characterization of cutaneous hormone production through analysis of skin secretions

The skin acts as an endocrine organ capable of hormone production and response. Moreover, conditions such acne, hirsutism, androgenetic alopecia, hidradenitis suppurativa clinically improve with anti-androgen therapies. Despite their importance, we have incomplete understanding the composition hormones produced by skin. In our current study, characterized hormonal landscape across anatomical sites between sexes through analysis secretions. this observational pilot collected secretions from antecubital fossa, forehead, back, axilla twelve male ten female subjects using commercially available, Sebutape. We then developed a method to extract quantify these liquid chromatography tandem mass spectrometry. were able detect seven observed site differences in glucocorticoids, cortisone 11-deoxycorticosterone. Most notably marked elevations dehydroepiandrosterone (p<0.0001) androstenedione on forehead (p<0.001). also detected several sex steroid consistent known systemic sexes. conclusion, reliable locally found that varies based site. Through approach, can determine how may be altered diseases.